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Senna Leaf Clinical Studies

Study #1


“Senna leaves belong to the stimulant laxatives. Rhein-9-anthrone is the most important metabolite, which is produced by the bacteria of the large intestine. The mode of action is based on two mechanisms. Firstly, colonic motility is increased leading to a reduced transit time and reduced fluid absorption. Secondly, an influence on secretion processes by two concomitant mechanisms, namely inhibition of absorption of water and electrolytes (Na+,Cl-) into the colonic epithelial cells (antiabsorptive effect) and increase of the leakiness of the tight junctions and stimulation of secretion of water and electrolytes into the lumen of the colon (secretagogue effect), results in enhanced concentrations of fluid and electrolytes in the lumen of the colon.”


[Committee on Herbal Medicinal Products, Assessment Report on Cassia Senna L. and Cassia Angustifolia Vahl, Folium, European Medicines Agency, 27 April 2007, at ema.europa.eu/docs/en_GB/document_library/Herbal_HMPC_assessment_report/2009/12/WC500018219.pdf]  


Study #2


“Objectives-- To compare the efficacy and cost effectiveness of a senna-fibre combination and lactulose in treating constipation. . .  The senna-fibre combination was significantly more effective than lactulose at a lower cost.”


[A. P. Passmore et al, Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination, British Medical Journal, September 1993, 307:769-771]


Study #3


“Senna is extensively cultivated in many parts of the world including India. Leaf and plant extract (calcium sennoside) of this plant has been used as an herbal medicine for the treatment of constipation. The purgative (stimulant purgative) action of Cassia senna has been extensively studied. Its morphological characteristics, mechanism of action, pharmacokinetics, adverse reactions, contraindications, drug interaction are well understood.” 


[Vijay Agarwal and Meenakshi Bajpai, Pharmacognostical and Biological Studies on Senna & Its Products: An Overview, International Journal of Pharma and Bio Sciences 1(2):1-10]


Study #4


“The herb works by invigorating muscle contractions in the intestines. It acts neither as a sedative nor as a refrigerant, but has a slight, stimulating influence. Sennosides present in senna aggravate the lining in the large intestines resulting to peristaltic action or the contraction of the intestinal muscles and eventually leading to exodus of the bowels.” 


[C. Indu Rani et al, Senna: Small Shrub, Big Work, Science Tech Entrepreneur, April 2010, at techno-preneur.net/information-desk/sciencetech-magazine/2010/april10/Senna.pdf]

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