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Resveratrol Clinical Studies

Study #1


“Results from these studies should be of interest to those who are obese, diabetic and growing older," Dr. Liu said. "The findings should also provide important information on the development of novel therapeutic drugs for the treatment of these diseases.”


[University of Texas Health Science Center at San Antonio. Grape ingredient resveratrol increases beneficial fat hormone, ScienceDaily, Jan. 2011. Web. 15 Jul. 2011. at http://www.sciencedaily.com/releases/2011/01/110107150600.htm]


Study #2


“Resveratrol down-regulated the expression of PPAR, C/EBP, SREBP-1c, FAS, HSL, LPL and up-regulated the expression of genes regulating mitochondrial activity (SIRT3, UCP1 and Mfn2). These results indicate that resveratrol may alter fat mass by directly affecting cell viability and adipogenesis in maturing preadipocytes and inducing apoptosis in adipocytes and thus may have applications for the treatment of obesity.”


[Srujana Rayalam et al, Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes, Phytotherapy Research Volume 22 Issue 10 (2008): 1367–1371]


Study #3


“Resveratrol reduced the seasonal body-mass gain by concomitantly decreasing energy intake by 13% and increasing resting metabolic rate by 29%. Resveratrol supplementation inhibited the depth of daily torpor, an important energy-saving process...”


[Alexandre Dal-Pan et al, Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity, BMC Physiology (2010) 10:11]


Study #4


“Numerous beneficial effects of resveratrol described in the literature involve cardioprotective, anti-cancer, anti-inflammatory and antioxidant action. Recently, this broad spectrum of effects is enlarged by new data demonstrating a great potency of this compound in relation to obesity and diabetes.”


[Katarzyna Szkudelska and Tomasz Szkudelski, Resveratrol, obesity and diabetes, European Journal of Pharmacology 635 (2010):1–8]


Study #5


"If the metabolic syndrome can be considered a polar opposite to caloric restriction, then agents that mimic caloric restriction may offer a new therapeutic approach to preventing CVD. The authors discuss the cardioprotective effects of resveratrol and highlight its role in glucose homeostasis and lipid metabolism.”


[S. Sadruddin and R. Aurora, Resveratrol: Biologic and Therapeutic Implications, Journal of the CardioMetabolic Syndrome, Volume 4 Issue 2 (Spring 2009):102–106]  


Study #6


“Researchers from the University of Texas found that the antioxidant compound resveratrol stimulates the expression of adiponectin– a hormone released from fat cells, which plays an important role in the regulation of insulin sensitivity and energy.”


[Nathan Gray, Resveratrol’s health benefits linked to fat hormone control, Nutra-ingredients USA, at http://www.nutraingredients-usa.com/Research/Resveratrol-s-health-benefits-linked-to-fat-hormone-control]


Study #7


“The present study has demonstrated that normal female rats provided with a high-fat diet for a period of 8 weeks were associated with a significant elevation of blood pressure and extensive perivascular fibrosis in the myocardium despite a nonsignificant increase in body weight and a normal plasma lipid profile and glucose concentration. Furthermore, the blood pressure increase in rats fed a high-fat diet was prevented by the coadministration of the antioxidant resveratrol.”


[Marie-Claude Aubin, Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol, Journal of Pharmacology and Experimental Therapeutics (2008) 325:961-968]


Study #8


“The natural polyphenol resveratrol (RSV) displays a wide spectrum of health beneficial activities, yet the precise mechanisms remain to be fully elucidated. Here we show that RSV promotes the multimerization and cellular levels of adiponectin in 3T3-L1 adipocytes.” 


[Anping Wang et al, Up-regulation of Adiponectin by Resveratrol: The Essential Roles of the Akt/FOXO1 and AMPK Signaling Pathways and DsbA-L, Journal of Biological Chemistry, Jan. 2011, 286(1):60-6]


Study #9


“In this paper, a sensitive, precise, and selective analytical method has been developed for the identification and quantification of resveratrol metabolites in human low-density lipoprotein (LDL)...”


[Mireia Urpí-Sardà et al, Uptake of Diet Resveratrol into the Human Low-Density Lipoprotein. Identification and Quantification of Resveratrol Metabolites by Liquid Chromatography Coupled with Tandem Mass Spectrometry, Analytical Chemistry (2005) 77(10): 3149–3155]  

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