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N-Acetyl Cysteine (NAC) Clinical Studies

Study #1


"Acetylcysteine is safe and effective in fulminant hepatic failure after paracetamol overdose."


[R Keays et al. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991 Oct 26; 303(6809): 1026–1029.]


Study #2


"We concluded that intraoperative NAC administration during the anhepatic phase of liver transplantation significantly increased recipient IL-4 plasma levels before and after reperfusion, and IL-10 plasma values before reperfusion (I-3). These enhancements seemed to be associated with a protective effect against reperfusion injury." 


[Santiago FM et al. Effect of N-acetylcysteine administration on intraoperative plasma levels of interleukin-4 and interleukin-10 in liver transplant recipients. Transplant Proc. 2008 Nov;40(9):2978-80. doi: 10.1016/j.transproceed.2008.08.103.]

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