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Magnesium Citrate Clinical Studies

Study #1


"Mg i.v. may be a useful supplementary therapy for the clinical management of severe manic agitation. This open study needs double-blind confirmation."


[Angela Heiden et al. Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy. Psychiatry Research Volume 89, Issue 3, 27 December 1999, Pages 239–246]


Study #2


" In a small placebo-controlled trial, acamprosate was found to result in improvements on some sleep measures. In single, small, mostly open-label studies, quetiapine, triazolam, ritanserin, bright light and magnesium have shown efficacy, while chlormethiazole, scopolamine and melperone showed no difference or worsening. Conclusion: Trazodone has the most data suggesting efficacy. This finding is tempered by a study suggesting its association with a return to heavy drinking in some patients. Data regarding the efficacy of gabapentin are unclear at this point." 


[Kolla, Bhanu Prakash, Meghna Prabhdas Mansukhani, and Terry Schneekloth. "Pharmacological treatment of insomnia in alcohol recovery: a systematic review." Alcohol and alcoholism 46.5 (2011): 578-585.]

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