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L-Ornithine Clinical Studies

Study #1

 

“We examined the effects of L-ornithine administration on physical fatigue. In a double-blind, placebo-controlled, 2-way crossover study, 17 healthy volunteers were randomized to L-ornithine (2000 mg/d for 7 days and 6000 mg/d for 1 day as L-ornithine hydrochloride) or placebo for 8 days. The fatigue-inducing physical task consisted of workload trials on a cycle ergometer at fixed workloads for 2 hours on 2 occasions. We found that oral L-ornithine administration promoted lipid metabolism and activated the urea cycle from serum triacylglycerol, ketone bodies, free fatty acids, and blood ammonia level changing. L-ornithine significantly attenuated the subjective feeling of fatigue (measured by visual analog scale at postrecovery) compared with postload (P < .01).  Moreover, in female subjects, the subjective feeling of fatigue was significantly lower compared with the placebo group (P <.05)...In conclusion, these results suggest that L-ornithine administration promotes lipid metabolism and activates the urea cycle. We recommend L-ornithine intake as a nutritional supplement in cases of physical fatigue.”

 

[Tomohiro Sugino et al, L-Ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism, Nutrition Research, November 2008, 28(11):738–743]

 
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