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Guaraná Seed Extract Clinical Studies
Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink
"Guarana´ (Paullinia cupana H.B.K., Sapindaceae) is a rainforest vine that was domesticated in the Amazon for its caffeine-rich fruits. Guarana´ has long been used as a tonic and to treat various disorders in Brazil and abroad and became a national soda in Brazil about a century ago. In the last two decades or so, guarana´ has emerged as a key ingredient in various 'sports' and energy drinks as well as concoctions that allegedly boost one's libido. For some time, guarana´'s high caffeine content was thought to be a detriment because of health concerns about excessive intake of caffeine-rich drinks. But it is precisely this quality, and the fact that it has a mysterious name and comes from an exotic land, that has propelled guarana´ into a global beverage. . . . Guarana´ is known to help stave off hunger and it is used by people trying to lose weight."
[Nigel Smith1 and André Luiz Atroch, Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink, Evidence Based Complementary Alternative Medicine (2010) Sep;7(3):279-82.]
Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial
"A significant change of the Body Composition Improvement Index (BCI) was observed in the active extract group compared to placebo (p = 0.012). Weight, BMI, waist-to-hip ratio was not statistically different between groups. Body fat loss was greater in active group (p = 0.011) compared to placebo. A weight loss parameter corrected for exercise was introduced and found to be higher in active group (p = 0.046) than in placebo, meaning that the formula was more efficacious, due to a concurrently performed exercise program--a recommended strategy for life style modification.
CONCLUSIONS: A significant change of the Body Composition Improvement Index and the decrease in body fat was statistically significant in active extract subjects compared to placebo."
[T. Opala et al., Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial, European Journal of Medical Research, August 2006, 11(8):343-350.]
Weight loss and delayed gastric emptying following a South American herbal preparation [Mate-Guarana-Damiana] in overweight patients
"The herbal preparation, YGD capsules, significantly delayed gastric emptying, reduced the time to perceived gastric fullness and induced significant weight loss over 45 days in overweight patients treated in a primary health care context. Maintenance treatment given in an uncontrolled context resulted in no further weight loss, nor weight regain in the group as a whole. The herbal preparation is thus shown to be one that significantly modulates gastric emptying. Further clinical studies with dietetic monitoring of energy intake, dietary quality, satiety ratings, body weight and body composition are now indicated, and examination of the active principles contained in the three herbal components may prove rewarding."
[T. Anderson and J. Fogh, Weight loss and delayed gastric emptying following a South American herbal preparation [Mate-Guarana-Damiana] in overweight patients, Journal of Human Nutrition and Dietetics June 2001, 14(3):243-50.]
Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná
" This research supports previous findings demonstrating guaraná's cognition enhancing properties and provides evidence that its addition to a multi-vitamin-mineral supplement can improve cognitive performance and reduce the mental fatigue associated with sustained mental effort."
[D O Kennedy et al., Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana), Appetite (2008) Volume: 50, Issue: 2-3, Pages: 506-513 ]