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Grapefruit – powder Clinical Studies

Study #1


“The results indicate that olfactory stimulation with grapefruit oil and lemon oil caused a significant increase in sympathetic nerve activity; however, no significant change in discharge rate was recognized by water vapor stimulation. These observations clearly demonstrate that olfactory stimulation with flavor of the citron group (grapefruit and lemon) results in reflex activation in sympathetic outflow to the WAT of epididymis, which suggests an acceleration of lipolysis in WAT and a suppression in body weight gain.”


[Akira Niijima et al, Effect of Olfactory Stimulation with Flavor of Grapefruit Oil and Lemon Oil on the Activity of Sympathetic Branch in the White Adipose Tissue of the Epididymis, Experimental Biology and Medicine, 228:1190-1192 (2003)]


Study #2


“The present study investigated the lipolytic (break of fat stored) effect of a citrus-based polyphenolic dietary supplement Sinetrol at human adipocytes (ex vivo), body fat (clinical) and biochemical levels (inhibition of phosphodiesterase). Free fatty acids (FFA) release was used as indicator of human adipocyte lipolysis and Sinetrol activity has been compared with known lipolytic products (isoproterenol, theopylline and caffeine). Sinetrol stimulated significantly the lipolytic activity in a range of 6 fold greater than the control...” 


[Constantin Dallas et al, Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE), Phytomedicine, 2008 Oct, 15(10):783-92. Epub 2008 Jul 9]


Study #3


“A secondary analysis of those with the metabolic syndrome in  the four treatment groups demonstrated a significantly greater weight loss in the grapefruit, grapefruit capsule, and grapefruit juice groups compared with placebo (P < .02). There was also a significant reduction in 2-hour post-glucose insulin level in the grapefruit group compared with placebo. Half of a fresh grapefruit eaten before meals was associated with significant weight loss. In metabolic syndrome patients the effect was also seen with grapefruit products. Insulin resistance was improved with fresh grapefruit. Although the mechanism of this weight loss is unknown it would appear reasonable to include grapefruit in a weight reduction diet.”


[J. Fujioka et al, The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome, Journal of Medicinal Food, 2006 Spring 9(1):49-54]

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