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Fructooligosaccharides Clinical Studies

Study #1


"The clinical studies showed that fructooligosaccharides administration improved the intestinal flora, with subsequent relief of constipation, improved blood lipids in hyperlipidemia, and suppressed the production of intestinal putrefactivesubstances."


[Hidemasa HIDAKA et al, Effects of Fructooligosaccharides on Intestinal Flora and Human Health, Bifidobacteria and Microflora

Vol. 5 (1986) No. 1 P 37-50 ]


Study #2


"Fructo-oligosaccharides have an energy value of 6 kJ/g; they have no genotoxic, carcinogenic, or toxicological effects; and they are mildly laxative, although flatulence is often a complaint when large doses are taken.23 In controlled dietary studies with human volunteers, fructo-oligosaccharides (15 g/day) increased faecal bifidobacterial numbers 10-fold while reducing clostridia and enterobacteria counts, showing that species composition of the microbiota could be selectively manipulated through diet. In vitro, eight different bifidobacterial species that were grown on fructo-oligosaccharides produced inhibitory substances which were antagonistic, to various degrees, against salmonella, listeria, campylobacter, shigella, and vibrio.24 Feeding fructo-oligosaccharides (8 g/day) to elderly people increased faecal bifidobacteria 10-fold,25 while ingestion of soybean oligosaccharides (10 g/day) resulted in a smaller, though still appreciable increase in bifidobacteria.26 Fructo-oligosaccharides do more than promote bifidobacterial growth, however, and several other intestinal bacteria are clearly involved in their metabolism."


[Georde T MacFarlane and John H Cummings, Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health?, BMJ. Apr 10, 1999; 318(7189): 999–1003]


Study #3


"Fructooligosaccharides (FOS) are noted for their considerable bifidogenic power and higher production of butyrate, a short-chain fatty acid which is essential to the colonocyte."


[MA Losada and T Olleros, Towards a healthier diet for the colon: the influence of fructooligosaccharides and lactobacilli on intestinal health, Nutrition Research. Volume 22, Issues 1–2, January–February 2002, Pages 71–84]

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