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Chromium Picolinate Clinical Studies
Effects of Chromium Picolinate on Food Intake and Satiety
"Results: Study 1 demonstrated that CrPic, as compared to placebo, reduced food intake (P < 0.0001), hunger levels (P < 0.05), and fat cravings (P < 0.0001) and tended to decrease body weight (P=0.08). In study 2, intraperitoneal administration resulted in a subtle decrease in food intake at only the highest dose (P = 0.03). However, when administered centrally, CrPic dose-dependently decreased food intake (P < 0.05). Conclusions: These data suggest CrPic has a role in food intake regulation, which may be mediated by a direct effect on the brain."
[Stephen D Anton PhD et al., Effects of Chromium Picolinate on Food Intake and Satiety, Diabetes Technology & Therapeutics (2008) Volume 10, Number 5:405-412.]
Effects of Chromium Picolinate Supplementation on Body Composition: A Randomized, Double-Masked, Placebo-Controlled Study
"These data suggest that supplementation with CrP can lead to significant improvements in body composition when a BCI is used as the outcome criterion that represents a sum of the net gains in nonfat mass added to the sum of the net losses of body fat."
[Gilbert R Kaats et al., Effects of Chromium Picolinate Supplementation on Body Composition: A Randomized, Double-Masked, Placebo-Controlled Study, Current Therapeutic Research (October 1996) 57(10):747-756.]
A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving
"In a population of adults with atypical depression, most of whom were overweight or obese, CrPic produced improvement on the following HAM-D-29 items: appetite increase, increased eating, carbohydrate craving, and diurnal variation of feelings. In a subpopulation of patients with high carbohydrate craving, overall HAM-D-29 scores improved significantly in patients treated with CrPic compared with placebo. The results of this study suggest that the main effect of chromium was on carbohydrate craving and appetite regulation..."
[JP Docherty et al., A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving, Journal of Psychiatric Practice (September 2005), 11(5):302-14.]