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Ashwagandha Clinical Studies
"The investigations support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression in Ayurveda."
[SK Bhattacharya et al. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacology Biochemistry and Behavior, Volume 75, Issue 3, June 2003, Pages 547–555, Plants and the Central Nervous System.]
"Both these standard drugs were administered once, 30 min prior to the tests. WSG induced an anxiolytic effect, comparable to that produced by lorazepam, in the elevated plus-maze, social interaction and feeding latency in an unfamiliar environment, tests. Further, both WSG and lorazepam, reduced rat brain levels of tribulin, an endocoid marker of clinical anxiety, when the levels were increased following administration of the anxiogenic agent, pentylenetetrazole. WSG also exhibited an antidepressant effect, comparable with that induced by imipramine, in the forced swim-induced ‘behavioural despair’ and ‘learned helplessness’ tests. The investigations support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression in Ayurveda."
[SK Bhattacharya et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine, Volume 7, Issue 6, December 2000, Pages 463–469.]
"Withania somnifera, herbal rejuvenative tonic widely used by Ayurvedic physicians in India, was tested for its adaptogenic properties. Pretreatment with this drug increased the swimming endurance in mice. It prevented gastric ulcers induced chemically or by stress in rats. Milk-induced leucocytosis was also prevented in mice. The drug prevented increase in adrenal weight and decrease in ascorbic acid and Cortisol content of adrenals during stress. It appears to induce a state of non-specifically increased resistance (SNIR) during stress."
[N. Signh et al. Withania Somnifera (Ashwagandha), a Rejuvenating Herbal Drug Which Enhances Survival During Stress (an Adaptogen) 1982, Vol. 20, No. 1 , Pages 29-35. (doi:10.3109/13880208209083282)